Pyridines and derivatives
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- (8)
- (7)
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- (867)
- (5)
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- (19)
- (346)
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- (1)
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- (1)
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Pifithrin- (CAS 64984-31-2) is a cell-permeable small molecule that inhibits p53-mediated apoptosis by interfering with p53 s mitochondrial functions It directly disrupts the interaction between p53 and mitochondrial proteins such as Bcl-2 and Bcl-xL (Kd 0 82 mM for p53 Kd 0 80 mM for Bcl-xL) impeding p53 s role in apoptosis independent of its transcriptional activity In cell-based assays Pifithrin- (25 M) attenuated nutlin-3-induced apoptosis in ML-1 cells Additionally the compound selectively inhibits heat shock protein 70 (HSP70) activity and has been shown to protect murine thymocytes from DNA damage-induced injury Pifithrin- is widely used to investigate p53-dependent apoptosis and mitochondrial stress responses in biomedical research
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Medchemexpress LLC 2-Pyridinecarboxamide, 5-[2-(5-isoquinolinyl)ethynyl]-N-[4-(4-morpholinylmethyl)-3-(trifluoro... | 2803422-60-6 | 98.2% | 516.51 | 100 MG
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MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It can be used to probe cellular and biological effects of upregulated oxidative damage repair in nucleotide pools and to delay or abrogate tumorigenesis. This product is for research use only.
- Enhances endogenous MTH1 activity
- Significantly reduces 8-oxo-dG levels in cellular DNA
- Used to probe cellular and biological effects of upregulated oxidative damage repair
- May delay or abrogate tumorigenesis
- Available as a white to off-white solid
- Recommended storage conditions for powder include -20°C for 3 years or 4°C for 2 years
- Recommended storage conditions in solvent include -80°C for 6 months or -20°C for 1 month
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Medchemexpress LLC EMD-95885 | 178165-43-0 | 382.43 | 100 MG
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EMD-95885 is a selective NR2B-containing NMDA receptors antagonist with an IC₅₀ of 3.9 nM. It does not interact with other sites on the NMDA receptor.
- Target: iGluR
- Pathway: Membrane transporter/ion channel; neuronal signaling
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BIOHIPPO HIF1a-sh-RFP-Puro
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HIF1a-sh-RFP-Puro shRNA lentiviral vector expressing RFP with Puromycin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated HIF1a shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse hypoxia inducible factor 1 subunit alpha (HIF1a) The shRNA has been validated to meet or exceed 70% HIF1a knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
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Medchemexpress LLC Npd10084 PKM2 inhibitor | 1040706-91-9 | 99.7% | 345.39 | 1 ML
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NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. It disrupts the interaction between PKM2 and β-catenin or STAT3, thereby inhibiting downstream signaling.
- Demonstrates antiproliferative activity against colorectal cancer cells both in vitro and in vivo
- Targets pyruvate kinase muscle isoform 2 (PKM2)
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Selleck Chemical LLC MV1035-E1636-25MG
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MV1035 an inhibitor of ALKBH5 significantly reduces GBM U87-MG cell migration and invasiveness through inhibition of the RNA demethylase ALKBH5
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Medchemexpress LLC PEG2000-DMPE | 99.7% | 2676.25 | 50 MG
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PEG2000-DMPE can be used to synthesize a LNP. It enhances the entrapment efficiency depending on its increasing portion in the liposome. The optimal formulation for animal study is DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20.
- Can be used to synthesize a LNP
- Enhances entrapment efficiency
- Optimal formulation for animal study is DMPC/PEG2000-DMPE/CH=50/5/45 at a weight ratio of drug/lipid=1/20
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Medchemexpress LLC DSHS00884 | 675104-49-1 | 99.8% | 308.38 | 1 ML
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DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC50 of 10 μM. It stabilizes p53 levels in HPV-positive cells by blocking E6-mediated p53 degradation.
- Stabilizes p53 levels in HPV-positive cells
- Blocks E6-mediated p53 degradation
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Medchemexpress LLC C15H9Cl2NO2 | 79183-19-0 | 98.6% | 306.14 | 1 ML
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MDK83190 is a potent apoptosis activator that induces Apaf-1 oligomerization, increases procaspase-9 processing, and subsequently activates caspase-3 in a cytochrome c-dependent manner. It is intended for research use only and not for sale to patients.
- Potent apoptosis activator
- Induces Apaf-1 oligomerization
- Increases procaspase-9 processing
- Activates caspase-3 in a cyto c-dependent manner
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Medchemexpress LLC SPB 100mg | 858128-57-1 | 100MG
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SPB is a agent-linker conjugate for ADC with potent anti-inflammatory activity by using Xanthotoxol linked via the ADC linker
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